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This tutorial demonstrated how to set up and resolve a strongly cavitating pressure-driven flow through an orifice, using multiphase mixture model of ANSYS FLUENT with cavitation effects. You learned how to set the boundary conditions for an internal flow. A steady-state solution was calculated to simulate the formation of vapor in the neck of the flow after the section restriction at the orifice. A more computationally intensive transient calculation is necessary to accurately simulate the irregular cyclic process of bubble formation, growth, filling by water jet re-entry, and break-off.